This Australian Primary Health Care Research Institute (APHCRI) Centre of Research Excellence (CRE) was established in early 2011 and is funded by APHCRI for four years to address primary health care quality, governance, performance and sustainability issues identified within the national health reform agenda. This CRE, incorporating the clinical microsystem approach, will investigate improved models in regional governance and e-health, effective multidisciplinary teamwork, and primary care performance and accountability. The Research Streams have been chosen for their critical importance in areas of national significance and current government reform, and their suitability in meeting the need for strong research to guide decision-makers, clinicians and communities. The CRE’s overarching research aims to support Australian primary care as it moves from a series of disparate sectors to an integrated system, able to reliably engage in the reform challenges ahead. For more information about this CRE, please visit http://aphcricremicrosystems.org.au/